Stranger things have been thought up...
Take up a .500 S&W cartridge. Imagine it being shortened to 1" case length. Install a ~330gr soft wadcutter. Fill the case with enough fast powder to launch at 700 to 800fps (barely sonic, if at all).
Call it .500 Bulldog.
Make a revolver, roughly J-frame sized in the grip with a larger cylinder just long enough to fit our new cartridge. 5 shots. Make it bulldog style, with the removable cylinder pin (mostly for nostalgia, partly for strength and inexpensiveness). DAO hidden hammer.
Voila, here's a really nice crookthumper.